Published Manuscripts (since 2012)
- Khazan, N, Kim, K.K., Hansen, J.N., Singh, N.A., Moore, T., Snyder, C.W.A., Pandita, R., Strawderman, M., Fujihara, M., Takamura, Y., Jian, Y., Battaglia, N., Yano, N., Teramoto, Y., Arnold, L.A., Hopson, R., Kishor, K., Nayak, S., Ojha, D., Sharon, A., Ashton, J.M., Wang, J., Milano, M.T., Miyamoto, H., Linehan, D.C., Gerber, S.A., Kawar, N., Singh, A.P., Tabdanov, E.D., Dokholyan, N.V., Kakuta, H., Jurutka, P.W., Schor, N.F., Rowswell-Turner, R.B., Singh, R.K., Moore, R.G. (2022) Identification of a vitamin-D receptor antagonist, MeTC7, which inhibits the growth of xenograft and transgenic tumors in vivo. J. Med. Chem. 65:6039-6055.
- Manhas, K.R., Marshall, P.A., Wagner, C.E., Jurutka, P.W., Mancenido, M.V., Debray, H.Z. and Blattman, J.N. (2022) Rexinoids modulate effector T cell expression of mucosal homing markers CCR9 and a4b7 and induce their migration in vitro. Frontiers in Immunology 13:746484.
- Reich, L.A., Moerland, J.A., Leal, A.S., Zhang, D., Carapellucci, S. Lockwood, B., Jurutka, P.W., Marshall, P.A., Wagner, C.E. and Liby, K.T. (2022) The rexinoid V-125 reduces tumor growth in preclinical models of breast and lung cancer. Scientific Reports 12:293.
- Jurutka, P.W., Martino, O., Reshi, R., Mallick, S., Sabir, Z.L., Staniszewski, L.J.P., Warda, A., Maiorella, E., Minasian, A., Davidson, J., Ibrahim, S.J., Raban, S., Haddad, D., Khamisi, M., Suban, S.L., Dawson, B.J., Candia, R., Ziller, J.W., Lee, M.Y., Liu, C., Liu, W., Marshall, P.A., Welch, J.S. and Wagner, C.E. (2021) Modeling, Synthesis and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB). International Journal of Molecular Sciences 22:12371.
- Florea, A., Harris, R.B., Klimentidis, Y.C., Kohler, L.N., Jurutka, P.W. and Jacobs, E.T. (2021) Circulating Fibroblast Growth Factor-21 and risk of metachronous colorectal adenoma. J. Gastrointestinal Cancer 52:940-946.
- Mallick, S., Marshall, P.A., Wagner, C.E., Heck, M.C., Sabir, Z.L., Sabir, M.S., Dussik, C.M., Grozic, A., Kaneko, I. and Jurutka, P.W. (2021) Evaluating novel RXR agonists that induce ApoE and tyrosine hydroxylase in cultured human glioblastoma cells. ACS Chemical Neuroscience 12:857-871.
- Haussler, M.R., Livingston, S., Sabir, Z.L., Haussler, C.A. and Jurutka, P.W. (2021) Vitamin D receptor mediates a myriad of biological actions dependent on its 1,25-dihydroxyvitamin D ligand: Distinct regulatory themes revealed by induction of klotho and fibroblast growth factor-23. J. Bone and Mineral Research Plus 5(1):e10432.
- Livingston, S., Mallick, S., Lucas, D.A., Sabir, M.S., Sabir, Z.L., Purdin, H., Nidamanuri, S., Haussler, C.A., Haussler, M.R. and Jurutka, P.W. (2020) Pomegranate derivative urolithin A enhances vitamin D receptor signaling to amplify serotonin-related gene induction by 1,25-dihydroxyvitamin D. Biochemistry and Biophysics Reports 24:100825.
- Florea, A., Harris, R.B., Klimentidis, Y.C., Kohler, L.N., Jurutka, P.W. and Jacobs, E.T. (2020) Circulating Fibroblast Growth Factor-21 and risk of metachronous colorectal adenoma. J. Gastrointestinal Cancer, in press.
- Xu, H., Wang, Y., Zhao, J., Jurutka, P.W., Huang, D., Liu, L,. Zhang, L., Wang, S., Chen, Y. and Cheng, S. (2020) Triterpenes from Poria cocos are revealed as potential retinoid X receptor selective agonists based on cell and in silico evidence. Chemical Biology and Drug Design, Chemical Biology and Drug Design 95:493-502.
- Xu, H., Wang, Y., Jurutka, P.W., Wu, S., Chen, Y., Cao, C., Chen, G., Tian, B., Wang, S and Cheng, S. (2019) 16α-Hydroxytrametenolic acid from Poria cocos improves intestinal barrier function through the glucocorticoid receptor-mediated PI3K/Akt/NF-κB pathway. J. Agric. Food Chem. 67:10871-10879.
- Wagner, C.E. and Jurutka, P.W. (2019) Methods to generate an array of novel rexinoids by SAR on a potent retinoid X receptor agonist: A case study with NEt-TMN. Methods Mol Biol. 2019:109-121.
- Jurutka, P.W. and Wagner, C.E. (2019) Methods to assess activity and potency of rexinoids using rapid luciferase-based Assays: A case study with NEt-TMN. Methods Mol Biol. 2019:95-108.
- Zhang, D, Leal, A.S., Carapellucci, S., Shahani, P.H., Bhogal, J.S., Ibrahim, S., Raban, S., Jurutka, P.W., Marshall, P.A., Sporn, M.B., Wagner, C.E., Liby, K.T. (2019) Testing novel pyrimidinyl rexinoids: A new paradigm for evaluating rexinoids for cancer prevention. Cancer Prevention Research 12:211-224.
- Hackney-Price, J.F., Hanish, B.J., Wagner, C.E., Kaneko, I., Jurutka, P.W. and Marshall, P.A. (2018) Dataset on the response of Hut78 cells to novel rexinoids. Data in Brief 20:1797-1803.
- Sabir, M.S., Haussler, M.R., Mallick, S., Kaneko, I., Lucas, D.A., Haussler, C.A., Whitfield, G.K. and Jurutka, P.W. (2018) Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines. Genes and Nutrition 13:19-30.
- Hanish, B.J., Hackney-Price, J.F., Kaneko, I., Ma, N., van der Vaart, A., Wagner, C.E., Jurutka, P.W. and Marshall, P.A. (2018) A novel gene expression analytics-based approach to structure-aided design of rexinoids for development as next-generation cancer therapeutics. Steroids 135:36-49.
- Chamcheu, J.C., Rady, I., Chamcheu, R.N., Siddique, A.B., Bloch, M.B., Banang-Mbeumi, S., Babatunde, A.S., Uddin, M.B., Noubissi, F.K., Jurutka, P.W., Liu, Y.Y., Spiegelman, V.S., Whitfield, G.K and El Sayed, K.A. (2018) Graviola (annona muricata) exerts anti-proliferative, anti-clonogenic and pro-apoptotic effects in human non-melanoma skin cancer UW-BCC1 and A431 cells in vitro: involvement of hedgehog signaling. Int. J. Mol. Sci. 19:1791-1815.
- Karrys, A., Rady, I., Chamcheu, R.N., Sabir, M.S., Mallick, S., Chamcheu, J.C., Jurutka, P.W., Haussler, M.R. and Whitfield, G.K. (2018) Bioactive dietary VDR ligands regulate genes encoding biomarkers of skin repair that are associated with risk for psoriasis. Nutrients 10:174-194.
- Dussik, C.M., Hockley, M., Grozic, A., Kaneko, I., Zhang, L., Sabir, M.S., Park, J., Wang, J., Nickerson, C.A., Yale, S.H., Rall, C.J., Foxx-Orenstein, A.E., Borror, C.M., Sandrin, T.R. and Jurutka, P.W. (2018) Gene expression profiling and assessment of vitamin D and serotonin pathway variations in patients with irritable bowel syndrome. Journal of Neurogastroenterology and Motility 24:96-106.
- Sabir, M.S., Khan, Z., Hu, C., Galligan, M.A., Dussik, C.M., Mallick, S., Stone, A.D., Batie, S, Jacobs, E.T., Whitfield, G.K., Haussler, M.R., Heck, M.G. and Jurutka, P.W. (2017) SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation. J. Steroid Biochem. Mol. Biol. 172:117-129.
- Warren-Andersen, S., Shu, X.O., Cai, Q., Khankari, N.K., Steinwandel, M.D., Jurutka, P.W., Blot, W.J. and Zheng, W. (2017) Total and free circulating vitamin D and vitamin D binding protein in relation to colorectal cancer risk in a prospective study of African Americans. Cancer Epidemiol. Biomarkers Prev. 26:1242-1247.
- Kohler, L.N., Hibler, E.A., Harris, R.B., Oren, E., Roe, D.J., Jurutka, P.W. and Jacobs, E.T. (2017) Greater adherence to cancer prevention guidelines is associated with higher circulating concentrations of vitamin D metabolites in a cross-sectional analysis of pooled participants from 2 chemoprevention trials. J. Nutrition 147:421-429.
- Wagner, C.E., Marshall, P.A. and Jurutka, P.W. (2017) Rexinoids (Editorial). Current Topics in Medicinal Chemistry. 17:629-630.
- Wagner, C.E., Jurutka, P.W., Marshall, P.A. and Heck, M.C. (2017) Retinoid X receptor selective agonists and their synthetic methods. Current Topics in Medicinal Chemistry 17:742-767.
- Heck, M.C., Wagner, C.E., Shahani, P.H., MacNeill, M., Grozic, A., Darwaiz, T., Shimabuku, M., Deans, D.G., Robinson, N.M., Salama, S. H., Ziller, J.W., Ma, N., Gray, G.M., van der Vaart, A., Marshall, P.A. and Jurutka, P.W. (2016) Modeling, synthesis and biological evaluation of potential retinoid-x-receptor (RXR) selective agonists: novel analogs of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and 6-(ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic acid (NEt-TMN). J. Med. Chem. 59:8924-8940.
- Jacobs, E.T., Haussler, M.R., Alberts, D.S., Kohler, L.N., Lance, P., Martínez, M.E., Roe, D.J. and Jurutka, P.W. (2016) Association between circulating vitamin D metabolites and fecal bile acid concentrations. Cancer Prevention Research 9:589-97.
- Haussler, M.R., Saini, R.K., Sabir, M.S., Dussik, C.M., Khan, Z., Whitfield, G.K., Griffin, K.P., Kaneko, I. and Jurutka. P.W. (2016) Vitamin D nutrient-gene interactions and healthful aging. In Molecular Basis of Nutrition and Aging (Marco Malavolta, M. and Mocchegiani, E., eds.), Elsevier, New York, pp. 449-471.
- Jacobs, E.T., Kohler, L.N., Kunihiroand, A.G. and Jurutka, P.W. (2016) Vitamin D and colorectal, breast, and prostate cancers: A review of the epidemiological evidence. Journal of Cancer 7:232-240.
- Haussler, M.R., Whitfield, G.K., Haussler, C.A., Sabir, M.S., Khan, Z., Sandoval, R. and Jurutka, P.W. (2016) 1,25-Dihydroxyvitamin D and klotho: A tale of two renal hormones coming of age. Vitamins and Hormones 100:165-230.
- Hibler, E.A., Sardo-Molmenti, C.L., Dai, Q., Kohler, L.N., Andersen, S.W., Jurutka, P.W. and Jacobs, E.T. (2016) Physical activity, sedentary behavior, and vitamin D metabolites. Bone 83:248–255.
- Hibler, E.A., Klimentidis, Y.C., Jurutka, P.W., Kohler, L.N., Lance, P., Roe, D.J., Thompson, P.A. and Jacobs, E.T. (2015) CYP24A1 and CYP27B1 polymorphisms, concentrations of vitamin D metabolites, and odds of colorectal adenoma recurrence. Nutrition and Cancer 67:1131-41.
- Kaneko, I., Saini, R.K., Griffin, K.P., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2015) FGF23 gene regulation by 1,25-dihydroxyvitamin D: Opposing effects in adipocytes and osteocytes. Journal of Endocrinology, 226:155-166.
- Lee, W.P., Jena, S., Rodriguez, E.P., O’Donovan, S., Wagner, C.E., Jurutka, P.W. and Thompson, P.D. (2015) Distinct functional modes of SUMOylation for retinoid X receptor a. Biochem. Biophys. Res. Commun. 464:195-200.
- Kaneko, I., Sabir, M.S., Dussik, C.M., Whitfield, G.K., Karrys, A., Hsieh, J.C., Haussler, M.R., Meyer, M.B., Pike J.W. and Jurutka, P.W. (2015) 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: Implication for behavioral influences of vitamin D. FASEB J. 29:4023– 4035.
- Marshall, P.A., Jurutka, P.W., Wagner, C.E., van der Vaart, A., Kaneko, I., Chavez, P.I., Ma, N., Bhogal, J.S., Shahani, P., Swierski, J.C. and MacNeill, M. (2015) Analysis of differential secondary effects of novel rexinoids: Select rexinoid X receptor ligands demonstrate differentiated side effect profiles. Pharmacology Research & Perspectives 3:e00122.
- Dampf-Stone, A., Batie, S.F., Sabir, M.S., Jacobs, E.T., Lee, J.H., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2015) Resveratrol potentiates vitamin D and nuclear receptor signaling. J Cell Biochem. 116:1130–1143.
- Bea, J.W., Jurutka, P.W., Hibler, E.A., Lance, P., Martínez, M.E., Roe, D.J., Sardo Molmenti, C.L., Thompson, P.A. and Jacobs, E.T. (2015) Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components. Metabolism - Clinical and Experimental 64:447-59.
- Hibler, E.A., Jacobs, E.T., Dampf-Stone, A., Sardo, C.L., Galligan, M.A. and Jurutka, P.W. (2014) Associations between vitamin D binding protein isotypes, circulating 25(OH)D levels, and vitamin D metabolite uptake in colon cancer cells. Cancer Prev. Res. 7:426-434.
- Hibler, E.A., Sardo-Molmenti, C.L., Lance, P., Jurutka, P.W. and Jacobs, E.T. (2014) Associations between circulating 1,25(OH)2D concentration and odds of metachronous colorectal adenoma. Cancer Causes and Control 25:809-17.
- Lee, W.P., Jena, S., Doherty, D., Ventakesh, J., Schmidt, J., Furmick, J., Widener, T., Lemau, J., Jurutka, P.W. and Thompson, P.D. (2014) Sentrin/SUMO specific proteases as novel tissue-selective co-activator proteins that modulate signaling by vitamin D receptor. PLoS One 9:e89506.
- Austin, H.R., Hoss, E., Batie, S., Moffet, E., Jurutka, P.W., Haussler, M.R. and Whitfield, G.K. (2014) Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin. Biochem. Biophys. Res. Commun. 443:1275-9.
- Hsieh, J.C., Estess, R.C., Kaneko, I., Whitfield, G.K., Jurutka, P.W. and Haussler, M.R. (2014) Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes. J. Endocrinol. 220:165-178.
- Jurutka, P.W., Kaneko, I., Yang, J., Bhogal, J.S., Swierski, J.C., Tabacaru, C.R., Montano, L.A., Huynh, C.C, Jama, R.A., Mahelona, R.D., Sarnowski, J.T., Marcus, L.M., Quezada, A., Lemming, B., Tedesco, M.A., Fischer, A.J., Mohamed, S.A., Ziller, J.W., Ma, N., Gray, G.M., van der Vaart, A., Marshall, P.A. and Wagner, C.E. (2013) Modeling, Synthesis, and Biological Evaluation of Potential Retinoid 2 X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic Acid (CD3254). J. Med. Chem. 56:8432-8454.
- Hoss, E., Austin, H.R., Jurutka, PW., Haussler, M.R. and Whitfield, G.K. (2013) Control of late cornified envelope genes relevant to psoriasis risk: Upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin. Arch. Dermatol. Res. 305:867-78.
- Jacobs, E.T., Hibler, E.A., Lance, P., Sardo, C.L., Jurutka, P.W. (2013) Association between circulating concentrations of 25(OH)D and colorectal adenoma: A pooled analysis. Int. J. Cancer 113:2980-2988.
- Jacobs, E.T., Van Pelt, C., Forster, R., Zaidi, W., Hibler, E.A., Galligan, M., Haussler, M.R. and Jurutka, P.W. (2013) CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells. Cancer Research 73:2563-2573.
- Saini, R.K., Kaneko, I., Jurutka, P.W., Forster, R.E., Hsieh, A., Hsieh, J.C., Haussler, M.R. and Whitfield, G.K. (2013) 1,25-Dihydroxyvitamin D3 regulation of Fibroblast Growth Factor-23 expression in bone cells: Evidence for primary and secondary mechanisms modulated by leptin and IL-6. Calcif. Tissue Int. 92:339-353.
- Batie, S., Lee, J.H., Jama, R.A., Browder, D.O., Montano, L.A., Huynh, C.C., Marcus, L.M., Tsosie, D.G., Mohammed, Z., Trang, V., Marshall, P.A., Jurutka, P.W. and Wagner, C.E. (2013) Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists. Bioorg. Med. Chem. 21:693-702.
- Haussler, M.R., Whitfield, G.K., Kaneko, I., Haussler, C.A., Hsieh, D., Hsieh, J.C. and Jurutka, P.W. (2013) Molecular mechanisms of vitamin D action. Calcif. Tissue Int. 92:77-98.
- Jurutka, P.W., Whitfield, G.K., Forster, R., Batie, S., Lee, J. and Haussler, M.R. (2012) Vitamin D: A fountain of youth in gene regulation. In Vitamin D: Oxidation, Immunity and Aging (Gombart, A. ed.), Springer, New York, pp. 1-35.
- Furmick, J.K., Kaneko, I., Walsh, A.N., Yang, J., Bhogal, J.S., Gray, G.M., Baso, J.C., Browder, D.O., Prentice, J.L.S., Montano, L.A., Huynh, C.C., Marcus, L.M., Tsosie, D.G., Kwon, J.S., Quezada, A., Reyes, N.M., Lemming, B., Saini, P. Vaart, A. Groy, T.L., Marshall, P.A., Jurutka, P.W. and Wagner, C.E. (2012) Modeling, synthesis and biological evaluation of potential retinoid-X-receptor (RXR) selective agonists: Novel halogenated analogs of 4-[1-(3,5,5,8,8- pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). ChemMedChem 7:1551-1566.
- Marshall, P.A., Hernandez, Z., Kaneko, I., Widener, T.A., Tabacaru, C., Aguayo, I. and Jurutka, P.W. (2012) Discovery of novel vitamin D receptor interacting proteins that modulate 1,25-dihydroxyvitamin D3 signaling. J. Steroid Biochem. Mol. Biol. 132:147-159.
- Haussler, M.R., Whitfield, G.K., Kaneko, I., Forster, R., Saini, R., Hsieh, J.C., Haussler, C.A. and Jurutka, P.W. (2012) The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis. Rev. Endocr. Metab. Disord. 13:57-69.
- Hibler, E.A., Hu, C., Jurutka, P.W., Martinez, M.E. and Jacobs, E.T. (2012) Polymorphic variation in GC and CaSR and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia. Cancer Epidemiol. Biomarkers Prev. 21:368-375.
Published Abstracts
- Hong, J., Reshi, S.M., Sabir, Z., Wagner, C.E., Marshall, P.A. and Jurutka, P.W. (2022) Evaluation of novel drug candidates for the treatment of cancer and Alzheimer’s Disease. Proceedings of the WCBSUR Conference Annual Meeting 2022.
- Reshi, S.M., Mallick, S., Marshall, P.A., Wagner, C.E. and Jurutka, P.W. (2021) Therapeutic potential of novel rexinoids in prevention and treatment of Alzheimer's Disease. Proceedings of the Arizona Physiological Society Annual Meeting 2021.
- Warda, A., Staniszewski, L.J.P., Sabir, Z., Ron, E., Marshall, P.A., Wagner, C.E. and Jurutka, P.W. (2021) Development of novel bexarotene analogs for treating cutaneous T-cell lymphomas. FASEB J. 35(1):04737.
- Reshi, S.M., Mallick, S., Marshall, P.A., Wagner, C.E. and Jurutka, P.W. (2021) Therapeutic potential of novel rexinoids in prevention and treatment of cancer and Alzheimer's Disease. FASEB J. 35(1):04187.
- Nguyen, C., Wagner, C.E., Marshall, P.A., Jurutka, P.W. (2021) The vitamin D receptor and RXR heteropartner cooperate via synergistic activation to control target gene expression. FASEB J. 35(1):01848.
- Manhas, K., Marshall, P.A., Wagner, C.E., Jurutka, P.W. and Blattman, J.N. (2020) Addition of rexinoids during T cell activation enhances mucosal-homing receptor expression and migratory ability of effector cells in vitro. Journal of Immunology 204:232.16.
- Sabir, Z.L., Livingston, S., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2020) Vitamin D impacts NRF-2 signaling and antioxidation pathways that modulate cellular aging. FASEB J. 34(1):09913.
- Livingston, S., Lucas, D., Sabir, M.S., Mallick, S., Purdin, H., Nidamanuri, S., Whitfield, G.K., Haussler, C.A., Haussler, M.R and Jurutka, P.W. (2020) Nutraceuticals derived from pomegranate selectively enhance vitamin D receptor signaling to amplify key vitamin D target genes. FASEB J. 34(1):09440.
- Pedroza, M., Mallick, S., Marshall, P.A., Wagner, C.E. and Jurutka, P.W. (2020) Assessment of novel rexinoids for therapeutic potential in combating Alzheimer's Disease. FASEB J. 34(1):09060.
- Florea, A., Kohler, L., Trejo, M., Jurutka P.W., Klimentidis, Y., Harris, R., Lance, P., Jacobs, E.T. (2020) Circulating Fibroblast Growth Factor-21 and odds of metachronous colorectal adenoma. Proceedings of the American Society for Preventive Oncology Annual Meeting, 80T:69.
- Manhas, K., Blattman, J.N., Marshall, P.A., Wagner, C.E. and Jurutka, P.W. (2019) Novel vaccine adjuvants: exploring the potential of rexinoids to influence effector T cell homing to mucosal sites. Journal of Immunology 202:66.6.
- Guerrero, V., Purdin, H.G., Jurutka, P.W. and Watanabe, K.H. (2019) A mathematical model of ERα and ERβ responsiveness to 17β-estradiol in vitro. Proceedings of the Arizona-Nevada Academy of Science 54(1):22.
- Livingston, S., Lucas, D., Sabir, M.S., Mallick, S., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2019) Nutraceuticals derived from pomegranate selectively enhance vitamin D receptor signaling to amplify key vitamin D target genes. Proceedings of the Arizona Physiological Society Annual Meeting 2019.
- Livingston, S., Lucas, D., Sabir, M.S., Mallick, S., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2019) Nutraceuticals derived from pomegranate selectively enhance vitamin D receptor signaling to amplify key vitamin D target genes. Proceedings of the Arizona-Nevada Academy of Science 54(1):20.
- Mallick, S., Wagner, C.E., Heck, M.C., Sabir, M., Grozic, A., Kaneko, I. and Jurutka, P.W. (2019) Development of novel RXR agonists that induce apolipoprotein E (ApoE) and tyrosine hydroxylase (TH) in cultured human glioblastoma cells. Proceedings of the Arizona-Nevada Academy of Science 54(1):11.
- Purdin, H.G., Guerrero, V., Jurutka, P.W. and Watanabe, K. (2019) Evaluation and mathematical modeling of ERα and ERβ activities in estrogen target cells. Proceedings of the Arizona-Nevada Academy of Science 54(1):22.
- Warda, A., Staniszewski, L.J.P., Ron, E., Wagner, C.E. and Jurutka, P.W. (2019) An alternative to bexarotene in treating cutaneous T-cell lymphomas. Proceedings of the Arizona-Nevada Academy of Science 54(1):22.
- Livingston, S., Lucas, D., Sabir, M.S., Mallick, S., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2018) Pomegranate-derived nutraceuticals activate the vitamin D signaling pathway. Proceedings of the Arizona Physiological Society Annual Meeting, S19:19.
- Staniszewski, L.J.P., Shahani, P., Heck, M., Hasan, D.S., Wagner, C.E. and Jurutka, P.W. (2018) Assessment of novel VDR antagonists that mediate suppression of vitamin D signaling. Proceedings of the Arizona Physiological Society Annual Meeting, F27:34.
- Wagner, C.E., Minasian, A., Moen, G., Le, A., Lee, I., Abidali, A., Al Ezzi, A., Tromba, L., Ron, E.D., Staniszewski, L., Marshall, P.A. and Jurutka, P.W. (2018) Synthesis and biological evaluation of hydroxylated derivatives of bexarotene and analogs of NEt-TMN—A potent retinoid X receptor (RXR) agonist. FASEB J, Proceedings of the 4th International FASEB Conference on Retinoids.
- Lucas, D.A., Sabir, M.S., Mallick, S., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2018) Vitamin D stimulates serotonin production via induction of tryptophan hydroxylase 2 isoform in B14 rat medullary neurons. FASEB J. 32(1):Supplement 1.lb155.
- Staniszewski, L.J.P., Shahani, P., Heck, M., Hasan, D.S., Wagner, C.E. and Jurutka, P.W. (2018) Assessment of novel VDR antagonists that mediate suppression of vitamin D signaling. FASEB J. 32(1):Supplement 1.lb98.
- Khan, S., Khan, Z., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2018) Cooperative inhibition of Wnt/b-catenin signaling by klotho and vitamin D: implications for chemoprevention. FASEB J. 32(1):Supplement 1.lb146.
- Livingston, S., Lucas, D., Sabir, M.S., Mallick, S., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2018) Pomegranate-derived nutraceuticals activate the vitamin D signaling pathway. Proceedings of the Arizona-Nevada Academy of Science 53(1):13.
- Khan, S., Khan, Z., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2018) Cooperative inhibition of Wnt/b-catenin signaling by klotho and vitamin D: implications for chemoprevention. Proceedings of the Arizona-Nevada Academy of Science 53(1):12.
- Staniszewski, L.J.P., Shahani, P., Heck, M., Hasan, D.S., Wagner, C.E. and Jurutka, P.W. (2018) Assessment of novel VDR antagonists that mediate suppression of vitamin D signaling. Proceedings of the Arizona-Nevada Academy of Science 53(1):17.
- Noutsios, G.T., Raban, S.S., Grozić, A., Yale, S.H., Rall, C.J., Foxx-Orenstein, A.E., Jurutka, P.W. and Sandrin, T.R. (2018) 16S rRNA gene sequencing affords insights into possible roles of the gut microbiome in irritable bowel syndrome (IBS). Proceedings of the Arizona-Nevada Academy of Science 53(1):15.
- Lucas, D.A., Sabir, M.S., Mallick, S., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2018) Vitamin D stimulates serotonin production via induction of tryptophan hydroxylase 2 in rat medullary neurons. Proceedings of the Arizona-Nevada Academy of Science 53(1):15.
- Khan, S., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2017) Vitamin D and its nuclear receptor: role in dopamine and serotonin regulation. Proceedings of the Arizona-Nevada Academy of Science 52(1):22.
- Bains, S., Shahani, P., Wagner, C.E., Marshall, P.A., Kaneko, I., Heck, M. and Jurutka, P.W. (2017) The chemotherapeutic potenital of rexinoids for ERα-positive breast cancer. Proceedings of the Arizona-Nevada Academy of Science 52(1):14.
- Kohler, L.N., Hibler, E.A., Harris, R.B., Oren, E., Roe, D.J., Jurutka, P.W. and Jacobs, E.T. American Cancer Society Cancer prevention guidelines, vitamin D status, and colorectal adenoma. Proceedings of the 41st Annual ASPO Conference (2017).
- Kaneko, I., Saini, R.K., Whitfield, G.K., Ito, M., Segawa, H., Tatsumi, S., Miyamoto,K., Haussler, M.R., and Jurutka, P.W. (2016) FGF23: A Nurr1-dependent phosphaturic hormone gene that is transcriptionally regulated by 1,25-dihydroxyvitamin D. Proceedings of the 18th International Congress on Nutrition and Metabolism in Renal Disease.
- Khan, S., Khan, Z., Sandoval, R., Whitfield, G.K., Haussler, M.R., and Jurutka, P.W. The chemopreventive nutrient 1,25-dihydroxyvitamin D3 exerts differential effects on s-klotho and m-klotho cancer signaling. Proceedings of the Arizona-Nevada Academy of Science (2016).
- Khan, Z., Khan, S., Sandoval, R., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. Tumor suppressors klotho and 1,25-dihydroxyvitamin D3 cooperate via synergistic inhibition of oncogenic Wnt/b-catenin signaling. Proceedings of the Arizona-Nevada Academy of Science (2016).
- Grozic, A., Dussik, C.M., Bradley, A., Hockley, M., Zhang, L., Borror, C., Park, J., Wang, J., Yale, S., Foxx-Orenstein, A., Sandrin, T. and Jurutka, P.W. Identification of transcriptomic biomarkers for use in the diagnosis of irritable bowel syndrome (IBS). Proceedings of the Arizona-Nevada Academy of Science (2016).
- Shahani, P., Heck, M., Wagner, C., Marshall, P., Kaneko, I. and Jurutka, P.W. (2016) Evaluation of novel rexinoids as chemotherapeutics with reduced clinical side effects. Proceedings of the Arizona-Nevada Academy of Science.
- Jacobs, E.T., Haussler, M.R., Alberts, D.S., Martinez, M.E., Kohler, L.N., Roe, D.J., Lance, P. and Jurutka, P.W. (2016) Association between circulating vitamin D metabolites and fecal bile acid concentrations. Proceedings of the AZCC (online).
- Dussik, C., Grozic, A., Zhang, L., Hockley, M., Sabir, M., Kaneko, I., Galligan, M., Borror, C., Sandrin, T. and Jurutka, P.W. (2016) Characterization of vitamin D and serotonin pathway variations in patients with irritable bowel syndrome.
- Sabir, M.S., Dussik, C.M., Kaneko, I., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2016) Modulation of serotonin synthesis, reuptake, and degradation by 1,25-dihydroxyvitamin D: Potential relevance for neuropsychiatric disorders.
- Wagner, C.E., Jurutka, P.W., Marshall, P.A., Kaneko, I., Pritika, S., Seto, D.H., Varkey, J.M., Hum, C.L., Sarnowski, J.T., Wentzel, M.R. and Chhun, C. (2016) Synthesis and biological characterization of novel CD3254 analogs. Proceedings of the 251st ACS National Meeting.
- Wagner, C.E., Jurutka, P.W., Marshall, P.A., Heck, M.C., Pritika, S., Bains, S., MacNeill, M., Shimabuku, M., Robinson, N., Seto, D.H., Varkey, J.M. and Hum, C.L. (2016) Synthesis and biological characterization of novel NEt-TMN analogs. Proceedings of the 251st ACS National Meeting.
- Kaneko, I., Hsieh, J.C., Whitfield, G.K., Segawa, H., Miyamoto, K., Haussler, M.R. and Jurutka, P.W. 1,25-Dihydroxyvitamin D enhances human tryptophan hydroxylase gene expression through vitamin D responsive elements in human brain cells. Proceedings of the 12th Annual Asian Congress of Nutrition (2015).
- Khan, Z., Khan, S., Sandoval, R., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. (2016) Tumor Suppressors Klotho and 1,25-Dihydroxyvitamin D3 Cooperate via Synergistic Inhibition of Oncogenic Wnt/β-Catenin Signaling. FASEB Journal, vol. 30 no. 1, Supplement 1119.11.
- Khan, Z., Sandoval, R., Khan, S., Whitfield, G.K., Haussler M.R. and Jurutka, P.W. Klotho and ß-catenin: At the crossroads of aging and cancer. Proceedings of the Arizona-Nevada Academy of Science (2015).
- Sabir, M.S., Dussik, C.M., Whitfield, G.K., M.R. Haussler and Jurutka, P.W. Regulation of serotonin synthesis, oxidation, and re-uptake by vitamin D: Potential relevance for autism spectrum disorders. Proceedings of the Arizona-Nevada Academy of Science (2015).
- Sabir, M.S., Khan, Z., Dussik, C., Dampf-Stone, A., Batie, S.F., Galligan, M.A., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. Resveratrol and SIRT1 are novel positive modulators of vitamin D signaling via apparent deacetylation of VDR. Endocrine Review (2015).
- Sabir, M.S., Khan, Z., Dussik, C., Dampf-Stone, A., Batie, S.F., Galligan, M.A., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. Resveratrol and SIRT1 are novel positive modulators of vitamin D signaling via apparent deacetylation of VDR. Proceedings of the Arizona-Nevada Academy of Science (2015).
- Sabir, M.S., Khan, Z., Dussik, C., Dampf-Stone, A., Batie, S.F., Galligan, M.A., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. Resveratrol and SIRT1 are novel positive modulators of vitamin D signaling via apparent deacetylation of VDR. Proceedings of the AZCC (online) (2015).
- Sandoval, R., Khan, Z., Khan, S., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. Crosstalk between anti-aging klotho and anti-oxidative FOXO signaling in human kidney and colon. Proceedings of the Arizona-Nevada Academy of Science (2015).
- Shahani, P., Wagner, C.E., Marshall, P.A., Kaneko, I., Heck, M. and Jurutka, P.W. Biological evaluation of nitrogen substitution in the FDA-approved drug bexarotene and novel RXR selective agonists. Proceedings of the Arizona-Nevada Academy of Science (2015).
- Varkey, J., Hum, C., Seto, D., Jurutka, P.W., Wagner, C.E. and Marshall, P.A. Analysis of bexarotene analog-driven RXR homodimerization by yeast two hybrid. Proceedings of the Arizona-Nevada Academy of Science (2015).
- Wagner, C.E., Jurutka, P.W., Marshall, P.A., Kaneko, I., MacNeill, M., Yang, J., Bhogal, J.S., Swierski, J.S., Tabacaru, C.R., Ziller, J.W., Ma, N., Gray, G.M. and van der Vaart, A. Pyrimidine bexarotene (16) as a novel therapeutic to treat Alzheimer’s disease. Proceedings of the Arizona-Nevada Academy of Science (2015).
- Dussik, C.M., Hockley, M.M., Sabir, M.S., Kaneko, I., Zhang, L., Galligan, M.A., Sandrin, T.R. and Jurutka, P.W. Identification of differentially expressed genes as biomarkers for diagnosis of irritable bowel syndrome (IBS). Proceedings of the Arizona-Nevada Academy of Science (2014).
- Khan, Z., Sabir, M.S., Galligan, M.A., Dampf-Stone, A., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. The anti-aging gene, SIRT1, modulates vitamin D signaling via cell- and promoter-specific pathways. Proceedings of the Arizona-Nevada Academy of Science (2014).
- Sabir, M.S., Khan, Z., Galligan, M.A., Dampf-Stone, A., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. Vitamin D and resveratrol: A fountain of youth in gene regulation. Abstracts of the Annual Biomedical Research Conference for Minority Students (ABRCMS) Abstract Database (2014).
- Sabir, M.S., Khan, Z., Galligan, M.A., Dampf-Stone, A., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. Vitamin D and resveratrol: A fountain of youth in gene regulation. Journal on Nutrition, Health, and Aging (2014).
- Sabir, M.S., Khan, Z., Galligan, M.A., Dampf-Stone, A., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. Vitamin D and resveratrol: A fountain of youth in gene regulation. Proceedings of the American Association for the Advancement of Science Pacific Division (2014).
- Sabir, M.S., Khan, Z., Galligan, M.A., Dampf-Stone, A., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. Vitamin D and resveratrol: A fountain of youth in gene regulation. Proceedings of the Arizona-Nevada Academy of Science (2014).
- Seto, D., Hayes, V., Varkey, J., Jurutka, P.W., Wagner, C.E. and Marshall, P.A. Yeast two hybrid analysis of RXR ligands. Proceedings of the Arizona-Nevada Academy of Science (2014).
- Shahani, P., Wagner, C.E., Marshall, P.A., Kaneko, I. and Jurutka, P.W. Characterization of next generation novel RXR selective agonists to combat cancer and neurodegenerative diseases. Proceedings of the Arizona-Nevada Academy of Science (2014).
- Dampf-Stone, A., Batie, S.F., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. The putative role of resveratrol in SIRT-1-mediated modulation of the vitamin D pathway. Proceedings of the American Association for the Advancement of Science Pacific Division (2013).
- Dampf-Stone, A., Batie, S.F., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. The putative role of resveratrol in SIRT-1-mediated modulation of the vitamin D pathway. Proceedings of the Arizona-Nevada Academy of Science (2013).
- Hockley, M.M., Galligan, M.A., Lin Zhang, Sandrin, T.R. and Jurutka, P.W. Identification of differentially expressed genes as biomarkers for diagnosis of Irritable Bowel Syndrome (IBS): A pilot gene discovery hypothesis generating study. Proceedings of the American Association for the Advancement of Science Pacific Division (2013).
- Hockley, M.M., Galligan, M.A., Lin Zhang, Sandrin, T.R. and Jurutka, P.W. Identification of differentially expressed genes as biomarkers for diagnosis of Irritable Bowel Syndrome (IBS): A pilot gene discovery hypothesis generating study. Proceedings of the Arizona-Nevada Academy of Science (2013).
- Sabir, M.S., Dampf-Stone, A., Batie, S.F., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. Evaluation of resveratrol as a novel modulator of the FOXO and vitamin D pathways in colon cancer. Proceedings of the American Association for the Advancement of Science Pacific Division(2013).
- Sabir, M.S., Dampf-Stone, A., Batie, S.F., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. Evaluation of resveratrol as a novel modulator of the FOXO and vitamin D pathways in colon cancer. Proceedings of the Arizona-Nevada Academy of Science 48(1):3. (2013).
- Batie, S.F., Lee, J.H., Wagner, C.E., Galligan, M., Haussler, M.R. and Jurutka, P.W. Evaluation of novel curcumin analogs as biological activators of vitamin D receptor signaling. Proceedings of the Arizona-Nevada Academy of Science (2012).
- Bhogal, J., Yang, J., Tabacaru, C., Wagner, C.E., Marshall, P.A. and Jurutka, P.W. Evaluation of novel RXR agonists with improved efficacy and decreased potential for side effects in the treatment of cutaneous T-cell lymphoma. Proceedings of the Arizona-Nevada Academy of Science (2012).
- Dampf-Stone, A., Batie, S.F., Whitfield, G.K., Haussler, M.R. and Jurutka, P.W. The role of resveratrol as a modulator of the vitamin D pathway. Proceedings of the Arizona-Nevada Academy of Science (2012).
- Hibler, E.A., Hu, C., Jurutka, P.W., Martinez, M.E., Wagoner, C.L. and Jacobs, E.T. Effect of over-the-counter cholecalciferol supplementation on circulating vitamin D metabolite concentration. Abstracts of the 15th Workshop on Vitamin D (2012).
- Hibler, E.A., Jacobs, E.T. and Jurutka, P.W. GC-globulin and uptake of vitamin D metabolites in colon cancer cells. Abstracts of the 15th Workshop on Vitamin D (2012).
- Hibler, E.A., Jacobs, E.T. and Jurutka, P.W. Role of GC SNPs in uptake of 1a,25(OH)2D in colon cancer cells. Proceedings of the Post-GWAS Horizons in Molecular Epidemiology (2012).